Could Binana identify the interactions with cofactors?

[Khanh Nguyen]

I tried and saw that Binana worked well when identifying the interactions between ligand and protein. However, I am wondering whether it could identify the interactions between ligand and cofactors near the ligand. I tried but seemingly it cannot identify the interactions between ligand and other cofactors. Please consider it. Thank you.

[Jacob Durrant]

Thanks for reaching out re. BINANA. If you include the cofactor as part of the receptor along with the protein, BINANA should be able to detect interactions between the ligand and cofactors. You can capture the relevant interactions by considering the cofactor as part of the receptor. I hope this answer helps!

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