Gypsum-DL
![](https://durrantlab.pitt.edu/wp-content/uploads/2019/01/gypsum.png)
Gypsum-DL is a free, open-source program that converts 1D and 2D small-molecule representations (SMILES strings or flat SDF files) into 3D models. It outputs models with alternate ionization, tautomeric, chiral, cis/trans isomeric, and ring-conformational states.